Published studies were identified from searches of electronic databases. We searched Medline (OvidSP), Embase, Web of Science, the Cochrane library from inception until May 2016. The search strategy was based on combinations of medical subject headings (MeSH) and keywords and was not restricted to specific languages. The search strategy used in Medline (OvidSP) is presented in an additional file [see Additional file 2]. Search strategies for other databases were modified to meet the requirements of each database. The searches were supplemented by screening the bibliographies of relevant studies and systematic reviews. Potential ongoing studies were identified in the International Clinical Trials Registry Platform WHO ( ) and the Register for Clinical Trials ( ).
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